Objective: We performed a systematic review and meta-analysis of published demiological studies of developmental fluo-. ride neurotoxicity. Developmental Fluoride Neurotoxicity: Choi et al. Respond . fluoride neurotoxicity: a systematic review and meta-. analysis. Environ Health. “Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis” is a study published in Environmental Health.

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Effect of high fluoride water on intelligence of school children in India.

Developmental fluoride neurotoxicity: a systematic review and meta-analysis.

Community Saloon bar To do list What is going on? This is a critical abstract of a systematic review that meets the criteria for inclusion on DARE. Most studies were cross-sectional, but this study design would seem appropriate in a stable population where water supplies and fluoride concentrations have remained unchanged for many years. In other words, and yet again, this paper documents the risks of chronic fluoride toxicity, not water fluoridation.

IQ scores of children in the high-fluoride area were lower than those of children in the reference area.

Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis – RationalWiki

This study was supported by internal institutional funds. I 2 residual The study with a positive association reported an SMD estimate of 0. Using random-effects models, we estimated the standardized mean difference between exposed and reference groups across all studies.

Among the restricted sets of intelligence tests, the SMD for the model with only CRT-RC tests and drinking-water exposure and to a lesser extent the model with only CRT-RC tests was lower than that for all studies combined, although the difference did not appear to be significant. National Center for Biotechnology InformationU. Support Center Support Center.

Children Intelligence Scale Handbook. What a ghastly thing to see coming from real scientists, doing real science! The mean IQ of children in the high-fluoride area was significantly lower than that from the reference fluoride area.


Fluoride exposure to the developing brain, which is much more susceptible to injury caused by toxicants than is the mature brain, may possibly lead to permanent damage Grandjean and Landrigan We performed a systematic review and meta-analysis of published studies to investigate the effects of increased fluoride exposure and delayed neurobehavioral development. Revisw J Pediatr Dent.

The study reviewed data on IQ test scores for children living in areas of China, Mongolia, and Iran where fluoride nfurotoxicity were significantly higher than those of fluoridated public water systems in the United States. CRD commentary This review addressed a relevant public health issue with reasonable broad inclusion criteria.

Children in the high-fluoride group scored significantly lower than those in reference group.

Among the 27 studies, all but one study showed random-effect SMD estimates that indicated an inverse association, ranging from —0. It was unclear whether action was taken to avoid reviewer error or bias. Author information Article notes Copyright and License information Disclaimer. Authors’ objectives To investigate the effect of increased fluoride exposure on delayed neurobehavioral development in children.

Developmental neurotoxicity of industrial chemicals. Mean IQ was lower in children in coal-burning areas compared to those in the reference group. The authors noted that there was considerable diversity in the studies, leading to substantial unexplained heterogeneity in the results, which meant that the generalisability of the results was unclear.

Wechsler Children Intelligence Scale. To summarize the available literature, we performed a systematic review and meta-analysis of published studies on increased fluoride exposure in drinking water associated with neurodevelopmental delays.

Footnotes This study was supported by internal institutional funds. For concerns on copyright infringement please see: From the geographic distribution of the studies, it seems unlikely that fluoride-attributed neurotoxicity could be attributable to other water contaminants. Interpretation of small effect sizes in occupational and environmental neurotoxicity: Views Read Edit Fossil record.

Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis – Semantic Scholar

The authors declare they have no actual or potential competing financial interests. Unless explicitly noted otherwise, all content licensed as indicated by RationalWiki: We conducted sensitivity analyses restricted to studies using the same outcome assessment and having drinking-water fluoride as the only exposure.


Retrieved from ” https: Among the two covariates, year of publication 0. We evaluated heterogeneity among studies using the I 2 statistic, which represents the percentage of developmentla variation across all studies due to between-study heterogeneity Higgins and Thompson Large tracts of China have superficial fluoride-rich minerals with little, if any, likelihood of contamination by other neurotoxicants that would be associated with fluoride concentrations in drinking water.

Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. Six of developmenntal 34 studies identified were excluded because of missing information on the number of subjects or the mean and variance of the outcome [see Figure 1 for a study selection flow chart and Supplemental Material, Table S1 http: Assessment of study quality No quality assessment of included studies was reported.

Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis

We carried out an extensive review that includes epidemiological studies carried out in China. Characteristics of the fpuoride studies included are shown in Table 1 An et al. Topics Discussed in This Paper. Decreased intelligence in children and exposure to fluoride and arsenic in drinking water.

Relative risks that compared low or marginal intelligence versus normal intelligence based on CRT-RC were also extracted where reported. There was no evidence of publication bias.

Measurement of intelligence by drawing test among the children in the endemic area of Al-F combined toxicosis.